Toxicity of dysprosium shift reagents in the isolated perfused rat kidney.
Magn Reson Med
; 11(2): 267-74, 1989 Aug.
Article
en En
| MEDLINE
| ID: mdl-2779417
ABSTRACT
Sodium and water spectra were acquired from the isolated perfused rat kidney by using a double-tuned probe designed to have high X nucleus sensitivity and low 1H sensitivity. Both DyTTHA and DyPPP were used to distinguish intra and extracellular 23Na resonances before and after the onset of hypoxia. Only DyPPP was useful in separating the two compartments, with a maximal chemical shift difference produced at a concentration of 4.5 mM. Both shift reagents were nephrotoxic at concentrations under 5 mM and produced an immediate decrease in renal-concentrating capacity and increases in fractional sodium and potassium excretion and increased renal vascular resistance. These disturbances of renal physiological parameters were accompanied by progressive broadening of the renal H2O resonance. 1H NMR may be a subtle means of monitoring nephrotoxicity.
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Base de datos:
MEDLINE
Asunto principal:
Disprosio
/
Riñón
Idioma:
En
Revista:
Magn Reson Med
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
1989
Tipo del documento:
Article