Association Between PAI-1 Activity Levels and t-PA Antigen with Glycemic Status in Prediabetic Population.
Acta Med Indones
; 48(3): 200-206, 2016 Jul.
Article
en En
| MEDLINE
| ID: mdl-27840354
ABSTRACT
AIM:
to evaluate an association between fibrinolysis defect and glycemic status in prediabetic population by assessing the levels of t-PA antigen and PAI-1 activity.METHODS:
it was an observational study with cross-sectional approach. There were 72 subjects aged 30-50 years who had met the inclusion criteria. The diagnosis of diabetes mellitus (DM) and glycemic index were determined based on the American Diabetes Association (ADA) criteria. The PAI-1 and t-PA antigen levels were measured quantitatively using enzyme-linked immunosorbent assay (ELISA). Analysis between the levels of t-PA antigen and PAI-1 activity was performed using ANOVA.RESULTS:
the t-PA antigen level was significantly higher in subjects with impaired glucose tolerance (IGT) and impaired fasting blood glucose (IFBG) as well as subject with impaired fasting blood glucose (IFBG) than those with normal glucose tolerance (NGT) (p=0.047). The PAI-1 activity was significantly higher in subjects with IGT, IFBG and subjects with IFBG than NGT (p=0.024). There was a significant association between glycemic status in prediabetic subjects and PAI-1 activity (p=0.04).CONCLUSION:
the level of t-PA antigen and PAI-1 activity were significantly higher in prediabetic subjects than those with NGT; and there was a significant association between glycemic status in prediabetic subjects and PAI-1 activity.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Estado Prediabético
/
Inhibidor 1 de Activador Plasminogénico
/
Antígeno Polipéptido de Tejido
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Acta Med Indones
Año:
2016
Tipo del documento:
Article