Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?
Cardiovasc Ther
; 35(2)2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-27893195
ABSTRACT
Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a "vulnerable" state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)-induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
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Enfermedad de la Arteria Coronaria
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Fármacos Fotosensibilizantes
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Vasos Coronarios
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Síndrome Coronario Agudo
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Investigación Biomédica Traslacional
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Placa Aterosclerótica
Idioma:
En
Revista:
Cardiovasc Ther
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
TERAPEUTICA
Año:
2017
Tipo del documento:
Article