Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media.
Org Biomol Chem
; 15(1): 213-219, 2016 Dec 20.
Article
en En
| MEDLINE
| ID: mdl-27896353
ABSTRACT
A straightforward four-step synthesis leads to the preparation of C2-symmetric dithiols containing a central aromatic core and amino acid side chains. These building blocks allow the preparation of dynamic covalent libraries of pseudopeptidic macrocycles in aqueous media that cover a broad range of polarities, functional groups and bulkiness mirroring the diversity found in natural peptides. The versatility of the generated dynamic libraries has been illustrated by the amplification of two different members from the same library upon the action of two biologically relevant templates.
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Base de datos:
MEDLINE
Asunto principal:
Compuestos Macrocíclicos
/
Peptidomiméticos
/
Aminoácidos
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2016
Tipo del documento:
Article