Molecular modeling and statistical analysis in the design of derivatives of human dipeptidyl peptidase IV.

Pereira, Alison L E; Dos Santos, Gabriela B; Franco, Márcia S F; Federico, Leonardo B; da Silva, Carlos H T P; Santos, Cleydson B R

Pereira, Alison L E; Dos Santos, Gabriela B; Franco, Márcia S F; Federico, Leonardo B; da Silva, Carlos H T P; Santos, Cleydson B R.

Afiliación

Pereira ALE; a Laboratório de Pesquisas Forenses e Genômica, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.
Dos Santos GB; b Computational Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , São Paulo , Brazil.
Franco MSF; b Computational Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , São Paulo , Brazil.
Federico LB; b Computational Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , São Paulo , Brazil.
da Silva CHTP; b Computational Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , São Paulo , Brazil.
Santos CBR; b Computational Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , São Paulo , Brazil.

J Biomol Struct Dyn ; 36(2): 318-334, 2018 02.

Article en En | MEDLINE | ID: mdl-28027711

Asunto(s)

Diabetes Mellitus Tipo 2/tratamiento farmacológico; Dipeptidil Peptidasa 4/química; Inhibidores de la Dipeptidil-Peptidasa IV/química; Hipoglucemiantes/química; Sitios de Unión; Dipeptidil Peptidasa 4/efectos de los fármacos; Inhibidores de la Dipeptidil-Peptidasa IV/uso terapéutico; Péptido 1 Similar al Glucagón/química; Humanos; Hipoglucemiantes/uso terapéutico; Modelos Moleculares; Simulación del Acoplamiento Molecular; Relación Estructura-Actividad

Palabras clave

QSAR analysis; dipeptidyl peptidase IV; molecular modeling; pharmacokinetic and toxicological properties; statistical analysis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Dipeptidil Peptidasa 4 / Diabetes Mellitus Tipo 2 / Inhibidores de la Dipeptidil-Peptidasa IV / Hipoglucemiantes Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biomol Struct Dyn Año: 2018 Tipo del documento: Article

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