Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2.
Phytochemistry
; 136: 39-45, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-28043654
ABSTRACT
CK2 is a ubiquitous protein kinase involved in many cell functions. During the last years it became an interesting target in cancer research. A series of flavonoid compounds was tested as inhibitors of protein kinase CK2. Several substances were found to be highly active against both catalytic subunits with IC50 values below 1 µM in case of CK2α'. The most promising inhibitor we identified is chrysoeriol with IC50 values of 250 and 34 nM for CK2α and CK2α', respectively.
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Base de datos:
MEDLINE
Asunto principal:
Flavonas
/
Quinasa de la Caseína II
Idioma:
En
Revista:
Phytochemistry
Año:
2017
Tipo del documento:
Article