Lymphotoxin-ß Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer.

Hsu, Dennis Shin-Shian; Hwang, Wei-Lun; Yuh, Chiou-Hwa; Chu, Chen-Hsi; Ho, Yang-Hui; Chen, Pon-Bo; Lin, Han-Syuan; Lin, Hua-Kuo; Wu, Shih-Pei; Lin, Chih-Yi; Hsu, Wen-Hao; Lan, Hsin-Yi; Wang, Hsiao-Jung; Tai, Shyh-Kuan; Hung, Mien-Chie; Yang, Muh-Hwa

Hsu, Dennis Shin-Shian; Hwang, Wei-Lun; Yuh, Chiou-Hwa; Chu, Chen-Hsi; Ho, Yang-Hui; Chen, Pon-Bo; Lin, Han-Syuan; Lin, Hua-Kuo; Wu, Shih-Pei; Lin, Chih-Yi; Hsu, Wen-Hao; Lan, Hsin-Yi; Wang, Hsiao-Jung; Tai, Shyh-Kuan; Hung, Mien-Chie; Yang, Muh-Hwa.

Afiliación

Hsu DS; Genome Research Center, National Yang-Ming University, Taipei, Taiwan.
Hwang WL; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Yuh CH; Institute of Molecular and Genome Medicine, National Health Research Institutes, Zhunan, Taiwan.
Chu CH; Department of Life Science and Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Ho YH; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Chen PB; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Lin HS; Institute of Molecular and Genome Medicine, National Health Research Institutes, Zhunan, Taiwan.
Lin HK; Institute of Molecular and Genome Medicine, National Health Research Institutes, Zhunan, Taiwan.
Wu SP; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Lin CY; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Hsu WH; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Lan HY; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Wang HJ; Division of Experimental Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Tai SK; Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan.
Hung MC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Yang MH; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas.

Clin Cancer Res ; 23(15): 4388-4401, 2017 Aug 01.

Article en En | MEDLINE | ID: mdl-28196873

Asunto(s)

Carcinoma de Células Escamosas/tratamiento farmacológico; Transición Epitelial-Mesenquimal/genética; Receptores ErbB/genética; Neoplasias de Cabeza y Cuello/tratamiento farmacológico; Linfotoxina beta/genética; FN-kappa B/antagonistas & inhibidores; Animales; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/patología; Línea Celular Tumoral; Cetuximab/administración & dosificación; Cetuximab/efectos adversos; Modelos Animales de Enfermedad; Resistencia a Antineoplásicos/genética; Transición Epitelial-Mesenquimal/efectos de los fármacos; Receptores ErbB/antagonistas & inhibidores; Neoplasias de Cabeza y Cuello/genética; Neoplasias de Cabeza y Cuello/patología; Humanos; Ratones; Mutación; FN-kappa B/genética; Inhibidores de Proteínas Quinasas/administración & dosificación; Inhibidores de Proteínas Quinasas/efectos adversos; Proteína-Arginina N-Metiltransferasas/genética; Proteínas Represoras/genética; Factores de Transcripción de la Familia Snail/genética; Carcinoma de Células Escamosas de Cabeza y Cuello; Ensayos Antitumor por Modelo de Xenoinjerto; Pez Cebra; Proteínas de Pez Cebra/genética

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / FN-kappa B / Linfotoxina beta / Transición Epitelial-Mesenquimal / Receptores ErbB / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article

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