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Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.
Otieno, Monicah A; Snoeys, Jan; Lam, Wing; Ghosh, Avi; Player, Mark R; Pocai, Alessandro; Salter, Rhys; Simic, Damir; Skaggs, Hollie; Singh, Bhanu; Lim, Heng-Keang.
Afiliación
  • Otieno MA; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Snoeys J; Preclinical Development & Safety, Janssen Pharmaceutica NV, Beerse, Antwerpen BE 2340, Belgium.
  • Lam W; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Ghosh A; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Player MR; Cardiovascular & Metabolism, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Pocai A; Cardiovascular & Metabolism, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Salter R; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Simic D; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Skaggs H; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Singh B; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
  • Lim HK; Preclinical Development and Safety, Janssen Pharmaceuticals, Spring House, Pennsylvania 19477.
Toxicol Sci ; 163(2): 374-384, 2018 06 01.
Article en En | MEDLINE | ID: mdl-28206647
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonas / Benzofuranos / Mitocondrias Hepáticas / Hepatocitos / Proteínas Asociadas a Resistencia a Múltiples Medicamentos / Transportadores de Anión Orgánico / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonas / Benzofuranos / Mitocondrias Hepáticas / Hepatocitos / Proteínas Asociadas a Resistencia a Múltiples Medicamentos / Transportadores de Anión Orgánico / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2018 Tipo del documento: Article