Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.

Pakavathkumar, Prateep; Noël, Anastasia; Lecrux, Clotilde; Tubeleviciute-Aydin, Agne; Hamel, Edith; Ahlfors, Jan-Eric; LeBlanc, Andrea C

Pakavathkumar, Prateep; Noël, Anastasia; Lecrux, Clotilde; Tubeleviciute-Aydin, Agne; Hamel, Edith; Ahlfors, Jan-Eric; LeBlanc, Andrea C.

Afiliación

Pakavathkumar P; Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Ch. Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
Noël A; Department of Neurology and Neurosurgery, McGill University, 845 Sherbrooke O, Montreal, QC, H3A 0G4, Canada.
Lecrux C; Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Ch. Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
Tubeleviciute-Aydin A; Department of Neurology and Neurosurgery, McGill University, 845 Sherbrooke O, Montreal, QC, H3A 0G4, Canada.
Hamel E; Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Ahlfors JE; Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Ch. Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
LeBlanc AC; Department of Neurology and Neurosurgery, McGill University, 845 Sherbrooke O, Montreal, QC, H3A 0G4, Canada.

Mol Neurodegener ; 12(1): 22, 2017 02 28.

Article en En | MEDLINE | ID: mdl-28241839

Asunto(s)

Caspasa 6/efectos de los fármacos; Inhibidores de Caspasas/farmacología; Degeneración Nerviosa/patología; Neuronas/efectos de los fármacos; Fármacos Neuroprotectores/farmacología; Sulfonas/farmacología; Animales; Axones/efectos de los fármacos; Axones/enzimología; Western Blotting; Cromatografía Liquida; Trastornos del Conocimiento/patología; Modelos Animales de Enfermedad; Citometría de Flujo; Humanos; Concentración 50 Inhibidora; Ratones; Ratones Transgénicos; Microscopía Fluorescente; Microscopía de Contraste de Fase; Neuronas/enzimología; Espectrometría de Masas en Tándem

Palabras clave

Alzheimer disease; Axonal degeneration; Caspase-6; Caspase-6 transgenic mice; Caspases; Peptide inhibitors; Primary human neurons; Vinyl sulfone inhibitors

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonas / Fármacos Neuroprotectores / Caspasa 6 / Inhibidores de Caspasas / Degeneración Nerviosa / Neuronas Idioma: En Revista: Mol Neurodegener Año: 2017 Tipo del documento: Article

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