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Synthesis and Functional Characterization of Caffeic Acid Glucoside Using Leuconostoc mesenteroides Dextransucrase.
Nam, Seung-Hee; Kim, Young-Min; Walsh, Marie K; Wee, Young-Jung; Yang, Kwang-Yeol; Ko, Jin-A; Han, Songhee; Thanh Hanh Nguyen, Thi; Kim, Ji Young; Kim, Doman.
Afiliación
  • Walsh MK; Department of Nutrition, Dietetics, and Food Sciences, Utah State University , 8700 Old Main Hill, 750N 1200E, Logan, Utah 84322-8700, United States.
  • Wee YJ; Department of Food Science and Technology, Yeungnam University , Gyeongbuk 38541, South Korea.
J Agric Food Chem ; 65(13): 2743-2750, 2017 Apr 05.
Article en En | MEDLINE | ID: mdl-28271704
Caffeic acid was modified via transglucosylation using sucrose and dextransucrase from Leuconostoc mesenteroides B-512FMCM. Following enzymatic modification, a caffeic acid glucoside was isolated by butanol separation, silica gel chromatography, and preparative HPLC. The synthesized caffeic acid glucoside had a molecular mass-to-charge ratio of 365 m/z, and its structure was identified as caffeic acid-3-O-α-d-glucopyranoside. The production of this caffeic acid-3-O-α-d-glucopyranoside at a concentration of 153 mM was optimized using 325 mM caffeic acid, 355 mM sucrose, and 650 mU mL-1 dextransucrase in the synthesis reaction. In comparison with the caffeic acid, the caffeic acid-3-O-α-d-glucopyranoside displayed 3-fold higher water solubility, 1.66-fold higher antilipid peroxidation effect, 15% stronger inhibition of colon cancer cell growth, and 11.5-fold higher browning resistance. These results indicate that this caffeic acid-3-O-α-d-glucopyranoside may be a suitable functional component of food and pharmaceutical products.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Ácidos Cafeicos / Leuconostoc mesenteroides / Glucósidos / Glucosiltransferasas Idioma: En Revista: J Agric Food Chem Año: 2017 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Ácidos Cafeicos / Leuconostoc mesenteroides / Glucósidos / Glucosiltransferasas Idioma: En Revista: J Agric Food Chem Año: 2017 Tipo del documento: Article