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Mesenchymal Stem Cells Modulate Differentiation of Myeloid Progenitor Cells During Inflammation.
Amouzegar, Afsaneh; Mittal, Sharad K; Sahu, Anuradha; Sahu, Srikant K; Chauhan, Sunil K.
Afiliación
  • Amouzegar A; Massachusetts Eye and Ear, Schepens Eye Research Institute, Boston, Massachusetts, 02114, USA.
  • Mittal SK; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, 02114, USA.
  • Sahu A; Massachusetts Eye and Ear, Schepens Eye Research Institute, Boston, Massachusetts, 02114, USA.
  • Sahu SK; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, 02114, USA.
  • Chauhan SK; Massachusetts Eye and Ear, Schepens Eye Research Institute, Boston, Massachusetts, 02114, USA.
Stem Cells ; 35(6): 1532-1541, 2017 06.
Article en En | MEDLINE | ID: mdl-28295880
ABSTRACT
Mesenchymal stem cells (MSCs) possess distinct immunomodulatory properties and have tremendous potential for use in therapeutic applications in various inflammatory diseases. MSCs have been shown to regulate pathogenic functions of mature myeloid inflammatory cells, such as macrophages and neutrophils. Intriguingly, the capacity of MSCs to modulate differentiation of myeloid progenitors (MPs) to mature inflammatory cells remains unknown to date. Here, we report the novel finding that MSCs inhibit the expression of differentiation markers on MPs under inflammatory conditions. We demonstrate that the inhibitory effect of MSCs is dependent on direct cell-cell contact and that this intercellular contact is mediated through interaction of CD200 expressed by MSCs and CD200R1 expressed by MPs. Furthermore, using an injury model of sterile inflammation, we show that MSCs promote MP frequencies and suppress infiltration of inflammatory cells in the inflamed tissue. We also find that downregulation of CD200 in MSCs correlates with abrogation of their immunoregulatory function. Collectively, our study provides unequivocal evidence that MSCs inhibit differentiation of MPs in the inflammatory environment via CD200-CD200R1 interaction. Stem Cells 2017;351532-1541.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Células Progenitoras Mieloides / Células Madre Mesenquimatosas / Inflamación Tipo de estudio: Prognostic_studies Idioma: En Revista: Stem Cells Año: 2017 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Células Progenitoras Mieloides / Células Madre Mesenquimatosas / Inflamación Tipo de estudio: Prognostic_studies Idioma: En Revista: Stem Cells Año: 2017 Tipo del documento: Article