Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors.

Waters, Alicia M; Johnston, James M; Reddy, Alyssa T; Fiveash, John; Madan-Swain, Avi; Kachurak, Kara; Bag, Asim K; Gillespie, G Yancey; Markert, James M; Friedman, Gregory K

Waters, Alicia M; Johnston, James M; Reddy, Alyssa T; Fiveash, John; Madan-Swain, Avi; Kachurak, Kara; Bag, Asim K; Gillespie, G Yancey; Markert, James M; Friedman, Gregory K.

Afiliación

Waters AM; 1 Department of Surgery, Division of Pediatric Surgery, University of Alabama at Birmingham , Birmingham, Alabama.
Johnston JM; 2 Department of Neurosurgery, University of Alabama at Birmingham , Birmingham, Alabama.
Reddy AT; 3 Department of Pediatrics, Division of Hematology/Oncology, University of Alabama at Birmingham , Birmingham, Alabama.
Fiveash J; 4 Department of Radiation Oncology, University of Alabama at Birmingham , Birmingham, Alabama.
Madan-Swain A; 3 Department of Pediatrics, Division of Hematology/Oncology, University of Alabama at Birmingham , Birmingham, Alabama.
Kachurak K; 5 Division of Hematology/Oncology, Children's of Alabama , Birmingham, Alabama.
Bag AK; 6 Department of Radiology, University of Alabama at Birmingham , Birmingham, Alabama.
Gillespie GY; 2 Department of Neurosurgery, University of Alabama at Birmingham , Birmingham, Alabama.
Markert JM; 2 Department of Neurosurgery, University of Alabama at Birmingham , Birmingham, Alabama.
Friedman GK; 3 Department of Pediatrics, Division of Hematology/Oncology, University of Alabama at Birmingham , Birmingham, Alabama.

Hum Gene Ther Clin Dev ; 28(1): 7-16, 2017 03.

Article en En | MEDLINE | ID: mdl-28319448

Asunto(s)

Vectores Genéticos/administración & dosificación; Herpesvirus Humano 1/genética; Viroterapia Oncolítica; Proyectos de Investigación; Neoplasias Supratentoriales/genética; Neoplasias Supratentoriales/radioterapia; Adolescente; Adulto; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/radioterapia; Neoplasias Encefálicas/virología; Niño; Preescolar; Femenino; Terapia Genética; Humanos; Masculino; Recurrencia Local de Neoplasia/genética; Recurrencia Local de Neoplasia/radioterapia; Recurrencia Local de Neoplasia/virología; Virus Oncolíticos/genética; Seguridad; Neoplasias Supratentoriales/virología

Palabras clave

G207; HSV; brain tumors; oncolytic; pediatric; virotherapy

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proyectos de Investigación / Neoplasias Supratentoriales / Herpesvirus Humano 1 / Viroterapia Oncolítica / Vectores Genéticos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Idioma: En Revista: Hum Gene Ther Clin Dev Año: 2017 Tipo del documento: Article

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