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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Sharabi, Kfir; Lin, Hua; Tavares, Clint D J; Dominy, John E; Camporez, Joao Paulo; Perry, Rachel J; Schilling, Roger; Rines, Amy K; Lee, Jaemin; Hickey, Marc; Bennion, Melissa; Palmer, Michelle; Nag, Partha P; Bittker, Joshua A; Perez, José; Jedrychowski, Mark P; Ozcan, Umut; Gygi, Steve P; Kamenecka, Theodore M; Shulman, Gerald I; Schreiber, Stuart L; Griffin, Patrick R; Puigserver, Pere.
Afiliación
  • Sharabi K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Lin H; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA.
  • Tavares CDJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Dominy JE; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Camporez JP; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Perry RJ; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Schilling R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Rines AK; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Lee J; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02130, USA.
  • Hickey M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Bennion M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Palmer M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Nag PP; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Bittker JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Perez J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Jedrychowski MP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Ozcan U; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02130, USA.
  • Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Kamenecka TM; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA.
  • Shulman GI; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Schreiber SL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Griffin PR; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA.
  • Puigserver P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pere_puigserver@dfci.harvard.edu.
Cell ; 169(1): 148-160.e15, 2017 03 23.
Article en En | MEDLINE | ID: mdl-28340340
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Gluconeogénesis / Hipoglucemiantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Gluconeogénesis / Hipoglucemiantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Año: 2017 Tipo del documento: Article