MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos.
Dev Cell
; 40(6): 552-565.e5, 2017 03 27.
Article
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| MEDLINE
| ID: mdl-28350988
ABSTRACT
Proper functioning of an organism requires cells and tissues to behave in uniform, well-organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here, we carried out a multi-faceted and single-cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi-gene microRNA (miRNA) families. We found that embryos lacking particular miRNA-dependent signaling pathways develop a vascular trait similar to wild-type, but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We discovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vertebrados
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MicroARNs
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Embrión no Mamífero
Idioma:
En
Revista:
Dev Cell
Asunto de la revista:
EMBRIOLOGIA
Año:
2017
Tipo del documento:
Article