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An epigenetic aging clock for dogs and wolves.
Thompson, Michael J; vonHoldt, Bridgett; Horvath, Steve; Pellegrini, Matteo.
Afiliación
  • Thompson MJ; Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • vonHoldt B; Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.
  • Horvath S; Department of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  • Pellegrini M; Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Aging (Albany NY) ; 9(3): 1055-1068, 2017 03 28.
Article en En | MEDLINE | ID: mdl-28373601
ABSTRACT
Several articles describe highly accurate age estimation methods based on human DNA-methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA-methylation data from 46 domesticated dogs (Canis familiaris) and 62 wild gray wolves (C. lupus). By regressing chronological dog age on the resulting CpGs, we defined highly accurate multivariate age estimators for dogs (based on 41 CpGs), wolves (67 CpGs), and both combined (115 CpGs). Age related DNA methylation changes in canids implicate similar gene ontology categories as those observed in humans suggesting an evolutionarily conserved mechanism underlying age-related DNA methylation in mammals.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Envejecimiento / Metilación de ADN / Lobos / Epigénesis Genética / Perros Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Envejecimiento / Metilación de ADN / Lobos / Epigénesis Genética / Perros Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2017 Tipo del documento: Article