Formal synthesis of Thienamycin.
J Antibiot (Tokyo)
; 70(6): 781-787, 2017 Jun.
Article
en En
| MEDLINE
| ID: mdl-28377636
ABSTRACT
A formal synthesis of Thienamycin from ethyl (E)-crotonate and a cyclic five-membered nitrone derived from 2-deoxy-d-ribose is described. The synthesis involves 1,3-dipolar cycloaddition, cleavage of the N-O bond in the adduct, and intramolecular N-acylation to afford a bicyclic carbapenam skeleton. Subsequent transformations of the five-membered ring substituents provide the title compound.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carbapenémicos
/
Tienamicinas
/
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2017
Tipo del documento:
Article