Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs.
Physiol Res
; 66(Suppl 1): S21-S38, 2017 04 05.
Article
en En
| MEDLINE
| ID: mdl-28379027
ABSTRACT
MicroRNAs (miRNAs) are a class of short non-coding regulatory RNA molecules which play an important role in intracellular communication and cell signaling and which influence cellular processes such as proliferation, differentiation, and cellular death. Over the past two decades, the crucial role of microRNAs in controlling tissue homeostasis and disease in cardiovascular systems has become widely recognized. By controlling the expression levels of their targets, several miRNAs have been shown to modulate the function of endothelial cells (miR-221/222 and -126), vascular smooth muscle cells (miR-143/145) and macrophages (miR-33, -758, and -26), thereby regulating the development and progression of atherosclerosis. The stability of miRNAs within the blood suggests that circulating miRNAs may function as important biomarkers of disease development and progression. Numerous circulating miRNAs have been found to be dysregulated in a wide variety of different disease states, including diabetes, cancer, and cardiovascular disease.
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Base de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
MicroARNs
/
Secuencias Reguladoras de Ácido Ribonucleico
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Physiol Res
Asunto de la revista:
FISIOLOGIA
Año:
2017
Tipo del documento:
Article