Atypical thymic carcinoid manifesting with nephrotic-range proteinuria in a 7-year-old boy.
Pediatr Nephrol
; 32(8): 1465-1468, 2017 Aug.
Article
en En
| MEDLINE
| ID: mdl-28477260
ABSTRACT
BACKGROUND:
Nephrotic-range proteinuria as a paraneoplastic syndrome (PNS) is an exceptional presentation, especially in children. It is usually associated with hematologic malignancies. Solid tumors are very rare causes of proteinuria. CASE-DIAGNOSIS/TREATMENT We present the case of a 7-year-old boy with an extremely rare atypical thymic carcinoid accompanied by nephrotic-range proteinuria as PNS. The kidney biopsy was consistent with minimal change disease (MCD). Tests for a neuroendocrine tumor were performed due to symptoms of hypercortisolemia and an elevated concentration of chromogranin A in the serum. The chest computed tomography revealed a tumor in the anterior mediastinum, which was diagnosed as an atypical thymic carcinoid. A complete resolution of the nephrotic-range proteinuria was observed within 1 week after the first thoracoscopic surgery, with almost complete reduction of the tumor mass.CONCLUSIONS:
This extremely rare case shows that MCD can occur as a PNS even in children. Nephrotic-range proteinuria can be a symptom of malignant solid tumor. This case highlights the possibility of secondary causes of MCD in children.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndromes Paraneoplásicos
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Proteinuria
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Neoplasias del Timo
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Tumor Carcinoide
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Enfermedades Raras
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Idioma:
En
Revista:
Pediatr Nephrol
Asunto de la revista:
NEFROLOGIA
/
PEDIATRIA
Año:
2017
Tipo del documento:
Article