Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic <i>X. laevis</i> Models of Retinitis Pigmentosa.

Vent-Schmidt, Ruanne Y J; Wen, Runxia H; Zong, Zusheng; Chiu, Colette N; Tam, Beatrice M; May, Christopher G; Moritz, Orson L

Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic X. laevis Models of Retinitis Pigmentosa.

Vent-Schmidt, Ruanne Y J; Wen, Runxia H; Zong, Zusheng; Chiu, Colette N; Tam, Beatrice M; May, Christopher G; Moritz, Orson L.

Afiliación

Vent-Schmidt RYJ; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9.
Wen RH; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9.
Zong Z; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9.
Chiu CN; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9.
Tam BM; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9.
May CG; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9.
Moritz OL; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9 olmoritz@mail.ubc.ca.

J Neurosci ; 37(4): 1039-1054, 2017 01 25.

Article en En | MEDLINE | ID: mdl-28490005

Asunto(s)

Inhibidores de Histona Desacetilasas/uso terapéutico; Retinitis Pigmentosa/tratamiento farmacológico; Ácido Valproico/uso terapéutico; Animales; Autofagosomas/metabolismo; Inhibidores de Histona Desacetilasas/farmacología; Histonas/metabolismo; Humanos; Células Fotorreceptoras/efectos de los fármacos; Células Fotorreceptoras/metabolismo; Células Fotorreceptoras/ultraestructura; Retinitis Pigmentosa/genética; Retinitis Pigmentosa/metabolismo; Rodopsina/genética; Ácido Valproico/farmacología; Xenopus laevis

Palabras clave

HDAC inhibitor; autophagy; retinal degeneration; retinitis pigmentosa; rhodopsin; valproic acid

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Retinitis Pigmentosa / Ácido Valproico / Inhibidores de Histona Desacetilasas Tipo de estudio: Prognostic_studies Idioma: En Revista: J Neurosci Año: 2017 Tipo del documento: Article

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