HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6 Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China.
AIDS Res Hum Retroviruses
; 33(9): 977-983, 2017 Sep.
Article
en En
| MEDLINE
| ID: mdl-28509569
ABSTRACT
We examined sequence variation in the HIV-1 gag p6 region from 27 individuals infected with HIV-1 CRF07_BC. An additional 269 gag p6 sequences of CRF07_BC from the Los Alamos National Laboratory database were also analyzed. A unique deletion of seven amino acid (aa) (p6Δ7) (aa 30-36, PIDKELY, in the HXB2 genome) was observed to exist exclusively in CRF07_BC. Indeed, 54.1% (160/296) of the CRF07_BC sequences contained the p6Δ7 mutation. The prevalence of the p6Δ7 mutation was 37.2% (29/78) and 92.3% (48/52) in CRF07_BC-infected intravenous drug users and men who have sex with men (MSM), respectively. Our results demonstrate that the p6Δ7 mutation dominates in MSM infected by HIV-1 CRF07_BC in China and suggests that this deletion could serve as a useful marker for monitoring HIV-1 evolution and epidemic. In future studies, it will be of interest to determine whether such genotypic variation influences viral replication capacity and disease progression.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Genes gag
/
Infecciones por VIH
/
VIH-1
/
Eliminación de Secuencia
/
Productos del Gen gag del Virus de la Inmunodeficiencia Humana
/
Aminoácidos
Tipo de estudio:
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2017
Tipo del documento:
Article