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Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.
Bialucha, Carl U; Collins, Scott D; Li, Xiao; Saxena, Parmita; Zhang, Xiamei; Dürr, Clemens; Lafont, Bruno; Prieur, Pierric; Shim, Yeonju; Mosher, Rebecca; Lee, David; Ostrom, Lance; Hu, Tiancen; Bilic, Sanela; Rajlic, Ivana Liric; Capka, Vladimir; Jiang, Wei; Wagner, Joel P; Elliott, GiNell; Veloso, Artur; Piel, Jessica C; Flaherty, Meghan M; Mansfield, Keith G; Meseck, Emily K; Rubic-Schneider, Tina; London, Anne Serdakowski; Tschantz, William R; Kurz, Markus; Nguyen, Duc; Bourret, Aaron; Meyer, Matthew J; Faris, Jason E; Janatpour, Mary J; Chan, Vivien W; Yoder, Nicholas C; Catcott, Kalli C; McShea, Molly A; Sun, Xiuxia; Gao, Hui; Williams, Juliet; Hofmann, Francesco; Engelman, Jeffrey A; Ettenberg, Seth A; Sellers, William R; Lees, Emma.
Afiliación
  • Bialucha CU; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. carl_uli.bialucha@novartis.com.
  • Collins SD; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Li X; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Saxena P; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Zhang X; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Dürr C; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland.
  • Lafont B; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland.
  • Prieur P; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland.
  • Shim Y; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Mosher R; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Lee D; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Ostrom L; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Hu T; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Bilic S; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Rajlic IL; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Capka V; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Jiang W; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Wagner JP; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Elliott G; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Veloso A; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Piel JC; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Flaherty MM; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Mansfield KG; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Meseck EK; Novartis Institutes for Biomedical Research, East Hanover, New Jersey.
  • Rubic-Schneider T; Novartis Institutes for Biomedical Research, Campus Klybeckstrasse, Basel, Switzerland.
  • London AS; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Tschantz WR; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Kurz M; Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Nguyen D; Novartis Pharma, Cambridge, Massachusetts.
  • Bourret A; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Meyer MJ; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Faris JE; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Janatpour MJ; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Chan VW; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Yoder NC; ImmunoGen Inc., Waltham, Massachusetts.
  • Catcott KC; ImmunoGen Inc., Waltham, Massachusetts.
  • McShea MA; ImmunoGen Inc., Waltham, Massachusetts.
  • Sun X; ImmunoGen Inc., Waltham, Massachusetts.
  • Gao H; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Williams J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Hofmann F; Novartis Institutes for Biomedical Research, Campus Klybeckstrasse, Basel, Switzerland.
  • Engelman JA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Ettenberg SA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Sellers WR; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Lees E; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Cancer Discov ; 7(9): 1030-1045, 2017 09.
Article en En | MEDLINE | ID: mdl-28526733
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Cadherinas / Neoplasias Renales / Antineoplásicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancer Discov Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Cadherinas / Neoplasias Renales / Antineoplásicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancer Discov Año: 2017 Tipo del documento: Article