The Hispanic Paradox in endometrial cancer: A National Cancer Database study.
Gynecol Oncol
; 146(2): 351-358, 2017 08.
Article
en En
| MEDLINE
| ID: mdl-28549815
ABSTRACT
OBJECTIVE:
To compare the overall survival of non-Hispanic white and Hispanic women with endometrial cancer.METHODS:
We performed an observational retrospective cohort study of Hispanic and non-Hispanic women with endometrial cancer from the 2004-2014 National Cancer Database. Baseline characteristics were compared with the Chi-squared test for categorical variables or the Mann-Whitney U test for ordinal or continuous variables. The Kaplan-Meier method was used to estimate unadjusted survival times, which were compared with the log-rank test. Missing data was imputed using multiple imputation with chained equations. A multivariable parametric accelerated failure time model for survival was used. Sensitivity analyses were performed using matched cohort analyses of the overall cohort, and of subgroups based on stage or type.RESULTS:
112,574 non-Hispanic and 6313 Hispanic women met inclusion criteria. Five-year survival was slightly higher for Hispanic women (83.1% (82.1-84.3%) versus 81.4% (81.2-81.7%), P=0.002). Hispanic women were younger, treated at lower volume hospitals, and more often diagnosed with a type II histology and stage II-IV disease compared to non-Hispanic women (all P<0.001). With multivariable adjustment for measured confounders, Hispanic women lived 8% longer than non-Hispanic women (time-ratio (95% CI) 1.08 (1.02-1.14), P=0.01). When bias-reducing matched cohort analyses were used for sensitivity analyses, Hispanic women did not have significantly different survival than non-Hispanic women.CONCLUSION:
Hispanic ethnicity was not associated with a clinically meaningful difference in survival among women with endometrial cancer.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carcinosarcoma
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Hispánicos o Latinos
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Neoplasias Endometriales
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Neoplasias Quísticas, Mucinosas y Serosas
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Carcinoma Endometrioide
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Adenocarcinoma de Células Claras
/
Población Blanca
Tipo de estudio:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Gynecol Oncol
Año:
2017
Tipo del documento:
Article