PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells.

He, Miao; Ichinose, Takamichi; Yoshida, Seiichi; Ito, Tomohiro; He, Cuiying; Yoshida, Yasuhiro; Arashidani, Keiichi; Takano, Hirohisa; Sun, Guifan; Shibamoto, Takayuki

He, Miao; Ichinose, Takamichi; Yoshida, Seiichi; Ito, Tomohiro; He, Cuiying; Yoshida, Yasuhiro; Arashidani, Keiichi; Takano, Hirohisa; Sun, Guifan; Shibamoto, Takayuki.

Afiliación

He M; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China.
Ichinose T; Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, 870-1201, Japan.
Yoshida S; Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, 870-1201, Japan.
Ito T; Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, 870-1201, Japan.
He C; Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan.
Yoshida Y; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, 807-8555, Japan.
Arashidani K; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, 807-8555, Japan.
Takano H; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, 807-8555, Japan.
Sun G; Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, 615-8530, Japan.
Shibamoto T; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China.

J Appl Toxicol ; 37(10): 1203-1218, 2017 Oct.

Article en En | MEDLINE | ID: mdl-28555929

Asunto(s)

Células Epiteliales Alveolares/efectos de los fármacos; Biomarcadores/metabolismo; Macrófagos/efectos de los fármacos; Material Particulado/toxicidad; Neumonía/tratamiento farmacológico; Acetilcisteína/farmacología; Células Epiteliales Alveolares/citología; Animales; Líquido del Lavado Bronquioalveolar; Quimiocina CCL2/genética; Quimiocina CCL2/metabolismo; Ciclooxigenasa 2/genética; Ciclooxigenasa 2/metabolismo; Hemo-Oxigenasa 1/genética; Hemo-Oxigenasa 1/metabolismo; Interleucina-6/genética; Interleucina-6/metabolismo; Lipopolisacáridos/toxicidad; Pulmón/citología; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Macrófagos/citología; Masculino; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos BALB C; Factor 88 de Diferenciación Mieloide/genética; Factor 88 de Diferenciación Mieloide/metabolismo; FN-kappa B/genética; FN-kappa B/metabolismo; Tamaño de la Partícula; Neumonía/sangre; Neumonía/inducido químicamente; Hidrocarburos Policíclicos Aromáticos/análisis; Polimixina B/farmacología; Células RAW 264.7; Factor de Necrosis Tumoral alfa/genética; Factor de Necrosis Tumoral alfa/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/genética; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

MLE-12 cells; MyD88 KO; PM2.5; lung inflammation; macrophages; oxidative stress

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neumonía / Biomarcadores / Material Particulado / Células Epiteliales Alveolares / Macrófagos Idioma: En Revista: J Appl Toxicol Año: 2017 Tipo del documento: Article

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