Early infectious outcomes after addition of fluoroquinolone or aminoglycoside to posttrauma antibiotic prophylaxis in combat-related open fracture injuries.
J Trauma Acute Care Surg
; 83(5): 854-861, 2017 11.
Article
en En
| MEDLINE
| ID: mdl-28570348
ABSTRACT
BACKGROUND:
We examined combat-related open extremity fracture infections as a function of whether posttrauma antimicrobial prophylaxis included expanded Gram-negative (EGN) coverage.METHODS:
Military personnel with open extremity fractures sustained in Iraq and Afghanistan (2009-2014) who transferred to participating hospitals in the United States were assessed. The analysis was restricted to patients with a U.S. hospitalization period of ≥7 days. Prophylaxis was classified as narrow (e.g., IV cefazolin, clindamycin, and/or amoxicillin-clavulanate) or EGN, if the prophylactic regimen included fluoroquinolones and/or aminoglycosides.RESULTS:
The study population included 1,044 patients, of which 585 (56%) and 459 (44%) received narrow and EGN coverage, respectively (p < 0.001). Skin and soft-tissue infections (SSTIs) were more common among patients who received narrow prophylaxis compared to EGN coverage (28% vs. 22%; p = 0.029), whereas osteomyelitis rates were comparable between regimens (8%). Similar findings were noted when endpoints were measured at 2 and 4 weeks postinjury. There was no significant difference related to length of hospitalization between narrow and EGN regimens (median 34 and 32 days, respectively) or operating room visits (median 5 and 4). A higher proportion of EGN coverage patients had Gram-negative organisms isolated that were not susceptible to fluoroquinolones and/or aminoglycosides (49% vs. 40%; p < 0.001). In a Cox proportional model, narrow prophylaxis was independently associated with an increased risk of extremity SSTIs (hazard ratio 1.41; 95% confidence interval 1.09-1.83).DISCUSSION:
Despite seeing a small benefit with EGN coverage related to a reduction of SSTIs, it does not decrease the risk of osteomyelitis, and there seems to be a cost of increased antibiotic resistance associated with use. Overall, our findings support the current post-combat trauma antibiotic prophylaxis guidelines, which recommend the use of cefazolin or clindamycin with open fractures. LEVEL OF EVIDENCE Prognostic/Epidemiological, Level II; Therapy, level IV.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Profilaxis Antibiótica
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Fluoroquinolonas
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Fracturas Abiertas
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Aminoglicósidos
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Personal Militar
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Antibacterianos
Tipo de estudio:
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Qualitative_research
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Trauma Acute Care Surg
Año:
2017
Tipo del documento:
Article