Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway.

Taverna, Simona; Pucci, Marzia; Giallombardo, Marco; Di Bella, Maria Antonietta; Santarpia, Mariacarmela; Reclusa, Pablo; Gil-Bazo, Ignacio; Rolfo, Christian; Alessandro, Riccardo

Taverna, Simona; Pucci, Marzia; Giallombardo, Marco; Di Bella, Maria Antonietta; Santarpia, Mariacarmela; Reclusa, Pablo; Gil-Bazo, Ignacio; Rolfo, Christian; Alessandro, Riccardo.

Afiliación

Taverna S; Biopathology and Biomedical Methodology, Biology and Genetic section, University of Palermo, Palermo, Italy.
Pucci M; Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council, Palermo, Italy.
Giallombardo M; Biopathology and Biomedical Methodology, Biology and Genetic section, University of Palermo, Palermo, Italy.
Di Bella MA; Biopathology and Biomedical Methodology, Biology and Genetic section, University of Palermo, Palermo, Italy.
Santarpia M; Biopathology and Biomedical Methodology, Biology and Genetic section, University of Palermo, Palermo, Italy.
Reclusa P; Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy.
Gil-Bazo I; Phase I-Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital (UZA) and Center for Oncological Research (CORE) Antwerp University, Antwerp, Belgium.
Rolfo C; Clinica Universidad de Navarra - Center for Applied Medical Research, Pamplona, Spain.
Alessandro R; Phase I-Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital (UZA) and Center for Oncological Research (CORE) Antwerp University, Antwerp, Belgium. christian.rolfo@uza.be.

Sci Rep ; 7(1): 3170, 2017 06 09.

Article en En | MEDLINE | ID: mdl-28600504

Asunto(s)

Anfirregulina/genética; Neoplasias Óseas/genética; Carcinoma de Pulmón de Células no Pequeñas/genética; Regulación Neoplásica de la Expresión Génica; Neoplasias Pulmonares/genética; Osteoclastos/metabolismo; Anfirregulina/metabolismo; Animales; Transporte Biológico; Neoplasias Óseas/metabolismo; Neoplasias Óseas/secundario; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/patología; Diferenciación Celular; Línea Celular Tumoral; Técnicas de Cocultivo; Receptores ErbB/genética; Receptores ErbB/metabolismo; Exosomas/química; Exosomas/patología; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patología; Ratones; Osteoclastos/patología; Cultivo Primario de Células; Ligando RANK/genética; Ligando RANK/metabolismo; Células RAW 264.7; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteoclastos / Neoplasias Óseas / Regulación Neoplásica de la Expresión Génica / Carcinoma de Pulmón de Células no Pequeñas / Anfirregulina / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article

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