Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids.

Hamulakova, Slavka; Janovec, Ladislav; Soukup, Ondrej; Jun, Daniel; Kuca, Kamil

Hamulakova, Slavka; Janovec, Ladislav; Soukup, Ondrej; Jun, Daniel; Kuca, Kamil.

Afiliación

Hamulakova S; Department of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, P. J. Safarik University, Moyzesova 11, SK-041 67 Kosice, Slovak Republic. Electronic address: slavka.hamulakova@upjs.sk.
Janovec L; Department of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, P. J. Safarik University, Moyzesova 11, SK-041 67 Kosice, Slovak Republic.
Soukup O; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty Military Helath Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Jun D; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty Military Helath Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Kuca K; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanského 62, 500 03 Hradec Kralove, Czech Republic.

Int J Biol Macromol ; 104(Pt A): 333-338, 2017 Nov.

Article en En | MEDLINE | ID: mdl-28601645

Asunto(s)

Acetilcolinesterasa/metabolismo; Acridinas/química; Acridinas/farmacología; Inhibidores de la Colinesterasa/química; Inhibidores de la Colinesterasa/farmacología; Cumarinas/química; Simulación del Acoplamiento Molecular; Acetilcolinesterasa/química; Acridinas/síntesis química; Acridinas/metabolismo; Dominio Catalítico; Técnicas de Química Sintética; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/metabolismo; Humanos; Concentración 50 Inhibidora

Palabras clave

Acridine; Alzheimers disease; Cholinesterase; Cholinesterase inhibitors; Coumarin; Tacrine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Acridinas / Inhibidores de la Colinesterasa / Cumarinas / Simulación del Acoplamiento Molecular Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Biol Macromol Año: 2017 Tipo del documento: Article

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