Mycoplasma fermentans deacetylase promotes mammalian cell stress tolerance.
Microbiol Res
; 201: 1-11, 2017 Aug.
Article
en En
| MEDLINE
| ID: mdl-28602396
ABSTRACT
Mycoplasma fermentans is a pathogenic bacterium that infects humans and has potential pathogenic roles in respiratory, genital and rheumatoid diseases. NAD+-dependent deacetylase is involved in a wide range of pathophysiological processes and our studies have demonstrated that expression of mycoplasmal deacetylase in mammalian cells inhibits proliferation but promotes anti-starvation stress tolerance. Furthermore, mycoplasmal deacetylase is involved in cellular anti-oxidation, which correlates with changes in the proapoptotic proteins BIK, p21 and BIM. Mycoplasmal deacetylase binds to and deacetylates the FOXO3 protein, similar with mammalian SIRT2, and affects expression of the FOXO3 target gene BIM, resulting in inhibition of cell proliferation. Mycoplasmal deacetylase also alters the performance of cells under drug stress. This study expands our understanding of the potential molecular and cellular mechanisms of interaction between mycoplasmas and mammalian cells.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
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Mycoplasma fermentans
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Interacciones Huésped-Patógeno
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Hidrolasas
Idioma:
En
Revista:
Microbiol Res
Asunto de la revista:
MICROBIOLOGIA
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SAUDE AMBIENTAL
Año:
2017
Tipo del documento:
Article