Identification of a secondary mutation in the KIT kinase domain correlated with imatinib-resistance in a canine mast cell tumor.

Nakano, Yuko; Kobayashi, Masato; Bonkobara, Makoto; Takanosu, Masamine

Nakano, Yuko; Kobayashi, Masato; Bonkobara, Makoto; Takanosu, Masamine.

Afiliación

Nakano Y; Japan Small Animal Cancer Center, 2-27-4, Nakatomi-minami, Tokorozawa-shi, Saitama 359-0003, Japan; Division of Clinical Epidemiology, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.
Kobayashi M; Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Bonkobara M; Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Takanosu M; Nasunogahara Animal Clinic, 2-3574-98 Asaka, Ohtawara, Tochigi 324-0043, Japan. Electronic address: volkerhall@me.com.

Vet Immunol Immunopathol ; 188: 84-88, 2017 Jun.

Article en En | MEDLINE | ID: mdl-28615132

Asunto(s)

Antineoplásicos/uso terapéutico; Mesilato de Imatinib/uso terapéutico; Mastocitosis/veterinaria; Proteínas Proto-Oncogénicas c-kit/genética; Animales; Perros; Resistencia a Antineoplásicos/genética; Mastocitosis/tratamiento farmacológico; Mastocitosis/genética; Eliminación de Secuencia/genética

Palabras clave

Dog; Imatinib; Mast cell tumor; Mutation; Resistance; c-KIT

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Mastocitosis / Proteínas Proto-Oncogénicas c-kit / Mesilato de Imatinib / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Vet Immunol Immunopathol Año: 2017 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google