Legionella and Coxiella effectors: strength in diversity and activity.
Nat Rev Microbiol
; 15(10): 591-605, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28713154
ABSTRACT
Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host cells. These effectors are essential for the establishment of membrane-bound compartments known as replication vacuoles, which enable the survival and replication of bacteria inside host cells. The effectors interfere with diverse signalling pathways to co-opt host processes, such as vesicle trafficking, ubiquitylation, gene expression and lipid metabolism, to promote pathogen survival. In this Review, we explore Dot/Icm effectors from L. pneumophila and C. burnetii as key virulence factors, and we examine the biochemical and cell biological functions of these effectors and their roles in our understanding of bacterial virulence.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacuolas
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Legionella pneumophila
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Coxiella burnetii
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Sistemas de Secreción Tipo IV
Idioma:
En
Revista:
Nat Rev Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2017
Tipo del documento:
Article