An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody.

Tsukamoto, Hiroki; Yamagata, Yuki; Ukai, Ippo; Takeuchi, Shino; Okubo, Misaki; Kobayashi, Yohei; Kozakai, Sao; Kubota, Kanae; Numasaki, Muneo; Kanemitsu, Yoshitomi; Matsumoto, Yotaro; Tomioka, Yoshihisa

Tsukamoto, Hiroki; Yamagata, Yuki; Ukai, Ippo; Takeuchi, Shino; Okubo, Misaki; Kobayashi, Yohei; Kozakai, Sao; Kubota, Kanae; Numasaki, Muneo; Kanemitsu, Yoshitomi; Matsumoto, Yotaro; Tomioka, Yoshihisa.

Afiliación

Tsukamoto H; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Yamagata Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Ukai I; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Takeuchi S; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Okubo M; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Kobayashi Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Kozakai S; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Kubota K; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Numasaki M; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kanemitsu Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Matsumoto Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Tomioka Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

FEBS Lett ; 591(16): 2406-2416, 2017 08.

Article en En | MEDLINE | ID: mdl-28741733

Asunto(s)

Secuencias de Aminoácidos; Anticuerpos Monoclonales/inmunología; Epítopos/inmunología; Receptor Toll-Like 4/química; Receptor Toll-Like 4/inmunología; Secuencia de Aminoácidos; Animales; Línea Celular; Humanos; Lipopolisacáridos/farmacología; Ratones; Multimerización de Proteína; Estructura Cuaternaria de Proteína; Receptor Toll-Like 4/metabolismo

Palabras clave

MD-2; Toll-like receptor 4; epitope; inhibitory monoclonal antibody; leucine-rich repeat; lipopolysaccharide

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Secuencias de Aminoácidos / Receptor Toll-Like 4 / Anticuerpos Monoclonales / Epítopos Idioma: En Revista: FEBS Lett Año: 2017 Tipo del documento: Article

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