Effects of Ascorbic Acid on Tax, NF-&#954;B and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes.

Harakeh, Steve; Khalife, Jihane; Baydoun, Elias; Azar, Rania; Al-Hejin, Ahmed; Barbour, Elie; Azhar, Esam; Niedzwiecki, Aleksandra; Al Jaouni, Soad; Diab-Assaf, Mona; Kamal, Mohammad A; Rath, Mathias

Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes.

Harakeh, Steve; Khalife, Jihane; Baydoun, Elias; Azar, Rania; Al-Hejin, Ahmed; Barbour, Elie; Azhar, Esam; Niedzwiecki, Aleksandra; Al Jaouni, Soad; Diab-Assaf, Mona; Kamal, Mohammad A; Rath, Mathias.

Afiliación

Harakeh S; Special Infectious Agents Unit, King Fahd Medical Research Center; Yousef Abdullatif Jameel Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University (KAU) Jeddah 21589, Saudi Arabia.
Khalife J; Biology Department, American University of Beirut (AUB), Lebanon.
Baydoun E; Biology Department, American University of Beirut (AUB), Lebanon.
Azar R; Lebanese University, EDST ("Molecular Tumor-genesis and Anticancer Pharmacology"), Hadath, Lebanon.
Al-Hejin A; Biology Department, King Abdulaziz University P.O.Box: 80216, Jeddah 21589, Saudi Arabia.
Barbour E; Department of Agriculture, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon.
Azhar E; Special Infectious Agents Unit, King Fahd Medical Research Center; Yousef Abdullatif Jameel Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University (KAU) Jeddah 21589, Saudi Arabia.
Niedzwiecki A; Dr. Rath Research Institute, Santa Clara, CA, United States.
Al Jaouni S; Department of Pediatric Hematology/Oncology, KAU, Saudi Arabia.
Diab-Assaf M; Lebanese University, EDST ("Molecular Tumor-genesis and Anticancer Pharmacology"), Hadath, Lebanon.
Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.
Rath M; Enzymoics, Peterlee Place, Hebersham, NSW 2770, Australia.

Anticancer Agents Med Chem ; 18(2): 237-244, 2018.

Article en En | MEDLINE | ID: mdl-28745235

Asunto(s)

Antineoplásicos/farmacología; Ácido Ascórbico/farmacología; Productos del Gen tax/antagonistas & inhibidores; Virus Linfotrópico T Tipo 1 Humano/efectos de los fármacos; Metaloproteinasa 9 de la Matriz/metabolismo; FN-kappa B/antagonistas & inhibidores; Linfocitos T/efectos de los fármacos; Antineoplásicos/química; Ácido Ascórbico/síntesis química; Ácido Ascórbico/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Productos del Gen tax/genética; Productos del Gen tax/metabolismo; Virus Linfotrópico T Tipo 1 Humano/metabolismo; Humanos; Metaloproteinasa 9 de la Matriz/genética; Estructura Molecular; FN-kappa B/metabolismo; Relación Estructura-Actividad; Linfocitos T/metabolismo

Palabras clave

Acute T-cell leukemia; Ascorbic Acid (AA); Human T-cell Lymphotrophic Virus type I (HTLV1); Matrix metalloproteinase-9 (MMP-9); NF-κB pathway; Tax; antipoliferative effect.

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Linfocitos T / Virus Linfotrópico T Tipo 1 Humano / Productos del Gen tax / FN-kappa B / Metaloproteinasa 9 de la Matriz / Antineoplásicos Idioma: En Revista: Anticancer Agents Med Chem Asunto de la revista: ANTINEOPLASICOS / QUIMICA Año: 2018 Tipo del documento: Article

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