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Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.
Hwang, Joyce K; Wang, Chong; Du, Zhou; Meyers, Robin M; Kepler, Thomas B; Neuberg, Donna; Kwong, Peter D; Mascola, John R; Joyce, M Gordon; Bonsignori, Mattia; Haynes, Barton F; Yeap, Leng-Siew; Alt, Frederick W.
Afiliación
  • Hwang JK; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
  • Wang C; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
  • Du Z; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Meyers RM; Department of Genetics, Harvard Medical School, Boston, MA 02115.
  • Kepler TB; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
  • Neuberg D; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
  • Kwong PD; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Mascola JR; Department of Genetics, Harvard Medical School, Boston, MA 02115.
  • Joyce MG; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
  • Bonsignori M; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
  • Haynes BF; Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
  • Yeap LS; Department of Genetics, Harvard Medical School, Boston, MA 02115.
  • Alt FW; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
Proc Natl Acad Sci U S A ; 114(32): 8614-8619, 2017 08 08.
Article en En | MEDLINE | ID: mdl-28747530
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Linfocitos B / Anticuerpos Anti-VIH / VIH-1 / Hipermutación Somática de Inmunoglobulina / Anticuerpos Neutralizantes / Anticuerpos Monoclonales de Origen Murino / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Linfocitos B / Anticuerpos Anti-VIH / VIH-1 / Hipermutación Somática de Inmunoglobulina / Anticuerpos Neutralizantes / Anticuerpos Monoclonales de Origen Murino / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article