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Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability.
Zhou, Nan; Yan, Yugang; Liu, Chunxi; Hou, Jinning; Xu, Wenfang; Zhang, Yingjie.
Afiliación
  • Zhou N; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 250012, PR China; Drug Research and Development Center, Shandong Drug and Food Vocational College, Weihai, Shandong 264210, PR China.
  • Yan Y; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Liu C; Department of Pharmacy, Qilu Hospital, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Hou J; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Xu W; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 250012, PR China; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 250012, PR China. Electronic address: zha
Bioorg Med Chem ; 25(17): 4614-4619, 2017 09 01.
Article en En | MEDLINE | ID: mdl-28757101
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Bencimidazoles / Tetrahidroisoquinolinas / Inhibidores de Histona Desacetilasas Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Bencimidazoles / Tetrahidroisoquinolinas / Inhibidores de Histona Desacetilasas Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article