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Draft Genome Sequences of Three ß-Lactam-Catabolizing Soil Proteobacteria.
Crofts, Terence S; Wang, Bin; Spivak, Aaron; Gianoulis, Tara A; Forsberg, Kevin J; Gibson, Molly K; Johnsky, Lauren A; Broomall, Stacey M; Rosenzweig, C Nicole; Skowronski, Evan W; Gibbons, Henry S; Sommer, Morten O A; Dantas, Gautam.
Afiliación
  • Crofts TS; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA tcrofts@path.wustl.edu.
  • Wang B; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Spivak A; Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Gianoulis TA; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Forsberg KJ; Wyss Institute for Biologically Inspired Engineering, Harvard, Cambridge, Massachusetts, USA.
  • Gibson MK; Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Johnsky LA; Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Broomall SM; U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA.
  • Rosenzweig CN; U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA.
  • Skowronski EW; U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA.
  • Gibbons HS; OptiMetrics, Inc., Abingdon, Maryland, USA.
  • Sommer MOA; U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA.
  • Dantas G; U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA.
Genome Announc ; 5(32)2017 Aug 10.
Article en En | MEDLINE | ID: mdl-28798166
ABSTRACT
Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil Proteobacteria identified for subsisting solely on ß-lactams as their carbon sources. The genomes encode multiple ß-lactamases, although their antibiotic catabolic pathways remain enigmatic.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Genome Announc Año: 2017 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Genome Announc Año: 2017 Tipo del documento: Article