Naphthoquinone rich Onosma visianii Clem (Boraginaceae) root extracts induce apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines.
Nat Prod Res
; 32(22): 2712-2716, 2018 Nov.
Article
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| MEDLINE
| ID: mdl-28882053
ABSTRACT
In the present study, five root extracts of Onosma visianii Clem were investigated for their in vitro cytotoxic activity. On the basis of HPLC-PDA analysis, these extracts have proved to be a rich source of naphthoquinones as natural colourants for food and cosmetic industry. All investigated root extracts contain acetylshikonin, isobutyrylshikonin and α-methylbutyrylshikonin as major compounds. As the most abundant source of active compounds for antitumour therapy, acetone, chloroform and ethyl acetate extracts showed strong cytotoxic activity towards HCT-116 and MDA-MB-231 cancer cell lines. Also, these extracts induced apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines.
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MEDLINE
Asunto principal:
Extractos Vegetales
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Naftoquinonas
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Apoptosis
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Boraginaceae
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Puntos de Control del Ciclo Celular
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Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Nat Prod Res
Año:
2018
Tipo del documento:
Article