Bioadhesive and biocompatible films as wound dressing materials based on a novel dendronized chitosan loaded with ciprofloxacin.
Carbohydr Polym
; 175: 75-86, 2017 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-28917926
ABSTRACT
The bioadhesive polymeric films as topical drug delivery systems are interesting alternatives to improve the pharmacotherapy and patient compliances. New derivate biomaterials based on weisocyanate- dendronized PVP- crosslinked chitosan and loaded with ciprofloxacin (CIP), as model drug, were used to prepare bioadhesive films. Relevant in vitro/in vivo attributes to define main physicochemical and biopharmaceutical characteristics for topical wound-healing applications were evaluated. A high proportion of CIP, uniformly dispersed along throughout the film, was loaded. An extended release of CIP and different behaviors of release profiles, depending on the presence of dendron, were observed. The films loaded with CIP were effective in inhibiting the growth of both Gram positive and Gram negative bacteria. In addition, biocompatibility and bioadhesion into conjuntival-sacs of the rabbits suggests that these films have good properties to be applied over skin wounds for topical applications, allowing a reduction of the frequency of administration and improving the residence time of the films.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vendajes
/
Materiales Biocompatibles
/
Ciprofloxacina
/
Sistemas de Liberación de Medicamentos
/
Quitosano
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Carbohydr Polym
Año:
2017
Tipo del documento:
Article