T cell-mediated antitumor immune response eliminates skin tumors induced by mouse papillomavirus, MmuPV1.
Exp Mol Pathol
; 103(2): 181-190, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28939161
ABSTRACT
Previous studies of naturally occurring mouse papillomavirus (PV) MmuPV1-induced tumors in B6.Cg-Foxn1nu/nu mice suggest that T cell deficiency is necessary and sufficient for the development of such tumors. To confirm this, MmuPV1-induced tumors were transplanted from T cell-deficient mice into immunocompetent congenic mice. Consequently, the tumors regressed and eventually disappeared. The elimination of MmuPV1-infected skin/tumors in immunocompetent mice was consistent with the induction of antitumor T cell immunity. This was confirmed by adoptive cell experiments using hyperimmune splenocytes collected from graft-recipient mice. In the present study, such splenocytes were injected into T cell-deficient mice infected with MmuPV1, and they eliminated both early-stage and fully formed tumors. We clearly show that anti-tumor T cell immunity activated during tumor regression in immunocompetent mice effectively eliminates tumors developing in T cell-deficient congenic mice. The results corroborate the notion that PV-induced tumors are strongly linked to the immune status of the host, and that PV antigens are major anti-tumor antigens. Successful anti-PV T cell responses should, therefore, lead to effective anti-tumor immune therapy in human PV-infected patients.
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1
Base de datos:
MEDLINE
Asunto principal:
Papillomaviridae
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Neoplasias Cutáneas
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Linfocitos T
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Infecciones por Papillomavirus
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Modelos Animales de Enfermedad
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Inmunidad Celular
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Exp Mol Pathol
Año:
2017
Tipo del documento:
Article