Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study.
RMD Open
; 3(1): e000424, 2017.
Article
en En
| MEDLINE
| ID: mdl-28951782
ABSTRACT
OBJECTIVES:
Genetic variation in the renal urate transporters SLC2A9 (GLUT9) and SLC22A11 (OAT4) has been reported to interact with diuretics to increase the risk of developing gout. The aim of this study was to determine whether variation in SLC2A9 or SLC22A11 influences acute renal handling of uric acid in response to frusemide.METHODS:
Following an overnight fast, healthy participants (n=100) attended a study visit with oral intake of 40â mg frusemide. Blood and urine samples were obtained at baseline and 30, 60, 120 and 180â min after frusemide intake. The primary end point was change in fractional excretion of uric acid (FEUA).RESULTS:
Following intake of frusemide, FEUA initially increased (mean (SD) change from baseline +1.9% (3.0%) at 60â min, p<0.001) and then decreased (mean (SD) change from baseline -1.5% (2.1%) at 180â min, p<0.001). A very small increase in serum urate was observed over the study period (mean (SD) change from baseline 0.007 (0.01) mmol/L at 180â min, p<0.001). The presence of the urate-lowering and gout-protective alleles for SLC2A9 (rs11942223 and rs13129697) and SLC22A11 (rs207826) did not significantly alter the FEUA following a frusemide load. At both 60 and 180â min, change in fractional excretion of sodium was independently associated with change in FEUA (standardised ß≥0.40, p<0.001).CONCLUSIONS:
The tested variants in SLC2A9 and SLC22A11 do not influence acute changes in renal handling of uric acid in response to frusemide. TRIAL REGISTRATION NUMBER ACTRN12614000871640; Results.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
RMD Open
Año:
2017
Tipo del documento:
Article