Genome-Wide Mutagenesis of Dengue Virus Reveals Plasticity of the NS1 Protein and Enables Generation of Infectious Tagged Reporter Viruses.

Eyre, Nicholas S; Johnson, Stephen M; Eltahla, Auda A; Aloi, Maria; Aloia, Amanda L; McDevitt, Christopher A; Bull, Rowena A; Beard, Michael R

Eyre, Nicholas S; Johnson, Stephen M; Eltahla, Auda A; Aloi, Maria; Aloia, Amanda L; McDevitt, Christopher A; Bull, Rowena A; Beard, Michael R.

Afiliación

Eyre NS; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia nicholas.eyre@adelaide.edu.au michael.beard@adelaide.edu.au.
Johnson SM; Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
Eltahla AA; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Aloi M; Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
Aloia AL; Viral Immunology Systems Program, School of Medical Sciences, The Kirby Institute, UNSW, Sydney, Australia.
McDevitt CA; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Bull RA; Cell Screen SA, Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, Australia.
Beard MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia.

J Virol ; 91(23)2017 12 01.

Article en En | MEDLINE | ID: mdl-28956770

Asunto(s)

Virus del Dengue/genética; Genoma Viral; Mutagénesis Insercional; Proteínas no Estructurales Virales/genética; Replicación Viral/genética; Línea Celular; ADN-(Sitio Apurínico o Apirimidínico) Liasa/genética; Virus del Dengue/fisiología; Virus del Dengue/ultraestructura; Endonucleasas; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Microscopía Electrónica; Enzimas Multifuncionales; ARN Viral; Proteínas no Estructurales Virales/química; Proteínas no Estructurales Virales/metabolismo; Proteínas no Estructurales Virales/ultraestructura

Palabras clave

NS1; dengue virus; electron microscopy; mutagenesis; virus assembly; virus replication

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Replicación Viral / Mutagénesis Insercional / Genoma Viral / Proteínas no Estructurales Virales / Virus del Dengue Tipo de estudio: Prognostic_studies Idioma: En Revista: J Virol Año: 2017 Tipo del documento: Article

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