M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRÎ³-Chain, Grb2, and SHP-1.

Rajaram, Murugesan V S; Arnett, Eusondia; Azad, Abul K; Guirado, Evelyn; Ni, Bin; Gerberick, Abigail D; He, Li-Zhen; Keler, Tibor; Thomas, Lawrence J; Lafuse, William P; Schlesinger, Larry S

M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRÎ³-Chain, Grb2, and SHP-1.

Rajaram, Murugesan V S; Arnett, Eusondia; Azad, Abul K; Guirado, Evelyn; Ni, Bin; Gerberick, Abigail D; He, Li-Zhen; Keler, Tibor; Thomas, Lawrence J; Lafuse, William P; Schlesinger, Larry S.

Afiliación

Rajaram MVS; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA. Electronic address: murugesan.rajaram@osumc.edu.
Arnett E; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Azad AK; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Guirado E; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Ni B; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA; Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA.
Gerberick AD; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA.
He LZ; Celldex Therapeutics, Inc., Needham, MA 02723, USA.
Keler T; Celldex Therapeutics, Inc., Needham, MA 02723, USA.
Thomas LJ; Celldex Therapeutics, Inc., Needham, MA 02723, USA.
Lafuse WP; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Schlesinger LS; Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA. Electronic address: lschlesinger@txbiomed.org.

Cell Rep ; 21(1): 126-140, 2017 Oct 03.

Article en En | MEDLINE | ID: mdl-28978467

Asunto(s)

Proteína Adaptadora GRB2/genética; Interacciones Huésped-Patógeno; Lectinas Tipo C/genética; Macrófagos/metabolismo; Lectinas de Unión a Manosa/genética; Mycobacterium tuberculosis/metabolismo; Proteína Tirosina Fosfatasa no Receptora Tipo 6/genética; Receptores de Superficie Celular/genética; Receptores de IgG/genética; Proteína Adaptadora GRB2/metabolismo; Regulación de la Expresión Génica; Humanos; Lectinas Tipo C/metabolismo; Lisosomas/metabolismo; Lisosomas/microbiología; Macrófagos/microbiología; Receptor de Manosa; Lectinas de Unión a Manosa/metabolismo; Fusión de Membrana; Mycobacterium tuberculosis/crecimiento & desarrollo; Fagocitosis/genética; Fagosomas/metabolismo; Fagosomas/microbiología; Fosforilación; Cultivo Primario de Células; Unión Proteica; Proteína Tirosina Fosfatasa no Receptora Tipo 6/metabolismo; Receptores de Superficie Celular/metabolismo; Receptores de IgG/metabolismo; Transducción de Señal; Vesículas Transportadoras/metabolismo; Vesículas Transportadoras/microbiología; Tirosina/metabolismo; Proteína de Unión al GTP cdc42/genética; Proteína de Unión al GTP cdc42/metabolismo; Quinasas p21 Activadas/genética; Quinasas p21 Activadas/metabolismo; Proteínas de Unión al GTP rac/genética; Proteínas de Unión al GTP rac/metabolismo

Palabras clave

C-type lectin; Mycobacterium; human macrophage; lysosome; mannose receptor; phagosome; tuberculosis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores de IgG / Receptores de Superficie Celular / Lectinas Tipo C / Lectinas de Unión a Manosa / Proteína Adaptadora GRB2 / Proteína Tirosina Fosfatasa no Receptora Tipo 6 / Interacciones Huésped-Patógeno / Macrófagos / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2017 Tipo del documento: Article

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