The effect of killer cell immunoglobulin-like receptor genotype on outcome of hematopoietic stem cell transplantation from matched sibling.
Hum Immunol
; 78(11-12): 684-691, 2017 Nov.
Article
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| MEDLINE
| ID: mdl-28993188
ABSTRACT
The alloreactivity of natural killer (NK) cell after allogeneic hematopoietic stem cell transplantation (AHSCT) is regulated by the interaction between donor killer immunoglobulin-like receptors (KIRs) and recipient human leukocyte antigen (HLA)-class I molecules. The aim was to identify KIR genes, haplotypes and their HLA-class I ligands and to investigate their association with transplantation outcome. The study included 65 patient/donor pairs who received AHSCT from HLA-matched identical siblings. KIR genotyping was done for donors using reverse sequence specific oligonucleotide probes (rSSO) coupled with luminex technology, while HLA-C genotyping was performed in patients using rSSO strip assay. In multivariate analysis, KIR2DS4 was associated with significant reduced incidence of relapse (pâ¯=â¯.002). A trend towards reduced incidence of relapse was also observed with more than two KIR B motifs (pâ¯=â¯.09), whereas a significant increased relapse was associated with homozygous HLA-C2 ligand compared to combined C1/C2 and C1/C1 (pâ¯=â¯.04). Activating KIR2DS3 was associated with rapid leukocyte engraftment (pâ¯=â¯.02). While, KIR 2DL5 was associated with decreased CMV infection (pâ¯=â¯.03) and better platelets engraftment (pâ¯=â¯.05). KIR genes, haplotypes and HLA-C alleles have an impact on HSCT outcome. Better selection of donors with favorable KIR genotype can improve HLA-matched sibling HSCT outcome especially for AML patients.
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Asunto principal:
Leucemia Mieloide Aguda
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Trasplante de Células Madre Hematopoyéticas
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Receptores KIR
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Receptores KIR2DL5
Idioma:
En
Revista:
Hum Immunol
Año:
2017
Tipo del documento:
Article