Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair.
Int J Mol Sci
; 18(10)2017 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-29036938
ABSTRACT
Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding wound contraction. In this review we provide an overview of the current literature on the role of molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.
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Base de datos:
MEDLINE
Asunto principal:
Piel
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Cicatrización de Heridas
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Especies Reactivas de Oxígeno
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NADPH Oxidasas
Idioma:
En
Revista:
Int J Mol Sci
Año:
2017
Tipo del documento:
Article