HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXR&#945; and PPAR&#945; dysregulation: implications for HIV-specific pathogenesis of NAFLD.

Agarwal, Neeti; Iyer, Dinakar; Gabbi, Chiara; Saha, Pradip; Patel, Sanjeet G; Mo, Qianxing; Chang, Benny; Goswami, Biman; Schubert, Ulrich; Kopp, Jeffrey B; Lewis, Dorothy E; Balasubramanyam, Ashok

HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD.

Agarwal, Neeti; Iyer, Dinakar; Gabbi, Chiara; Saha, Pradip; Patel, Sanjeet G; Mo, Qianxing; Chang, Benny; Goswami, Biman; Schubert, Ulrich; Kopp, Jeffrey B; Lewis, Dorothy E; Balasubramanyam, Ashok.

Afiliación

Agarwal N; Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Iyer D; Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Gabbi C; Department of Molecular Biology, University of Houston, Houston, TX, USA.
Saha P; University of Houston, Department of Biology and Biochemistry, Houston, TX, USA.
Patel SG; Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Mo Q; Department of Surgery, UCLA, Los Angeles, CA, USA.
Chang B; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Goswami B; Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Schubert U; Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Kopp JB; Institute of Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Lewis DE; Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Balasubramanyam A; Division of Infectious Diseases, Department of Medicine, University of Texas Health Sciences Center, Houston, TX, USA.

Sci Rep ; 7(1): 13362, 2017 10 17.

Article en En | MEDLINE | ID: mdl-29042644

Asunto(s)

Productos del Gen vpr/metabolismo; Infecciones por VIH/complicaciones; Infecciones por VIH/genética; VIH-1/fisiología; Receptores X del Hígado/genética; Enfermedad del Hígado Graso no Alcohólico/etiología; PPAR alfa/genética; Animales; Modelos Animales de Enfermedad; Regulación de la Expresión Génica; Infecciones por VIH/virología; Hepatocitos/metabolismo; Metabolismo de los Lípidos; Pruebas de Función Hepática; Receptores X del Hígado/metabolismo; Masculino; Ratones; Ratones Transgénicos; Enfermedad del Hígado Graso no Alcohólico/diagnóstico; Enfermedad del Hígado Graso no Alcohólico/metabolismo; PPAR alfa/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Productos del Gen vpr / PPAR alfa / Enfermedad del Hígado Graso no Alcohólico / Receptores X del Hígado Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article

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