Clinical and Laboratory Factors Associated with Severe Dengue: A Case-Control Study of Hospitalized Children.
J Trop Pediatr
; 64(5): 373-381, 2018 10 01.
Article
en En
| MEDLINE
| ID: mdl-29059411
ABSTRACT
Background:
More than half of the hospitalizations because of dengue in Brazil occurred in children <15 years of age in 2007 and 2008, an unexpected change in the epidemiological pattern. We sought to determine clinical and laboratory parameters associated with severity.Methods:
A case-control study was conducted in three pediatric hospitals in Rio de Janeiro, Brazil; 233 laboratory-confirmed dengue patients were included 69 cases and 164 controls. Specific clinical and laboratory factors were assessed using univariate and multivariate logistic regression models.Results:
Lethargy [adjusted odds ratio (ORa) 9.15, 95% confidence interval (CI) 3.08-27.12], dyspnea (ORa 8.24, 95% CI 3.27-20.72) and abdominal pain (ORa 6.78, 95% CI 1.44-31.84) were independently associated with severe dengue in children. Lethargy and dyspnea presented as early as 72 and 48 h, respectively, before shock.Conclusions:
Abdominal pain and lethargy confirmed their role as warning signs, which along with dyspnea might be helpful in identifying cases progressing to severe dengue.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Dengue Grave
/
Virus del Dengue
/
Hospitalización
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Trop Pediatr
Año:
2018
Tipo del documento:
Article