eIF3: a factor for human health and disease.
RNA Biol
; 15(1): 26-34, 2018 01 02.
Article
en En
| MEDLINE
| ID: mdl-29099306
ABSTRACT
The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Biosíntesis de Proteínas
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Regulación de la Expresión Génica
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Factor 3 de Iniciación Eucariótica
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Terapia Molecular Dirigida
Idioma:
En
Revista:
RNA Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2018
Tipo del documento:
Article