Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.

Xia, Houjun; Wang, Wei; Crespo, Joel; Kryczek, Ilona; Li, Wei; Wei, Shuang; Bian, Zhaoqun; Maj, Tomasz; He, Mingxiao; Liu, Rebecca J; He, Youwen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Zou, Weiping

Xia, Houjun; Wang, Wei; Crespo, Joel; Kryczek, Ilona; Li, Wei; Wei, Shuang; Bian, Zhaoqun; Maj, Tomasz; He, Mingxiao; Liu, Rebecca J; He, Youwen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Zou, Weiping.

Afiliación

Xia H; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Wang W; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Crespo J; Department of Immunology and Key Laboratory of Medical Immunology of Ministry of Public Health, Peking University Health Science Center, Beijing 100191, China.
Kryczek I; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Li W; Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Wei S; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Bian Z; Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Maj T; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
He M; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Liu RJ; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
He Y; Department of Environmental Health, Cincinnati University College of Medicine, Cincinnati, OH 45267, USA.
Rattan R; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Munkarah A; Department of Immunology, School of Medicine, Duke University, Durham, NC 27710, USA.
Guan JL; Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Zou W; Department of Immunology, School of Medicine, Duke University, Durham, NC 27710, USA.

Sci Immunol ; 2(17)2017 11 17.

Article en En | MEDLINE | ID: mdl-29150439

Asunto(s)

Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Ácido Láctico/farmacología; Neoplasias Ováricas/metabolismo; Proteínas Tirosina Quinasas/metabolismo; Linfocitos T/efectos de los fármacos; Animales; Apoptosis/genética; Autofagia/genética; Proteínas Relacionadas con la Autofagia; Línea Celular Tumoral; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Péptidos y Proteínas de Señalización Intracelular/genética; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Ácido Láctico/metabolismo; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Transgénicos; Neoplasias Experimentales/genética; Neoplasias Experimentales/metabolismo; Neoplasias Experimentales/patología; Neoplasias Ováricas/genética; Neoplasias Ováricas/patología; Proteínas Tirosina Quinasas/genética; Linfocitos T/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Autofagia / Proteínas Tirosina Quinasas / Linfocitos T / Apoptosis / Ácido Láctico Idioma: En Revista: Sci Immunol Año: 2017 Tipo del documento: Article

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