Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals.
Nat Neurosci
; 21(1): 29-32, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-29180747
ABSTRACT
Excitation of accumbal D2 cells governs vital actions, including avoidance of learned risks, but the origins of this excitation and roles of D2 cells in innate risk-avoidance are unclear. Hypothalamic neurons producing orexins (also called hypocretins) enhance innate risk-avoidance via poorly understood neurocircuits. We describe a direct orexinâD2 excitatory circuit and show that D2 cell activity is necessary for orexin-dependent innate risk-avoidance in mice, thus revealing an unsuspected hypothalamus-accumbens interplay in action selection.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
/
Transducción de Señal
/
Orexinas
/
Instinto
/
Neuronas
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2018
Tipo del documento:
Article