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A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
Chrovian, Christa C; Soyode-Johnson, Akinola; Peterson, Alexander A; Gelin, Christine F; Deng, Xiaohu; Dvorak, Curt A; Carruthers, Nicholas I; Lord, Brian; Fraser, Ian; Aluisio, Leah; Coe, Kevin J; Scott, Brian; Koudriakova, Tatiana; Schoetens, Freddy; Sepassi, Kia; Gallacher, David J; Bhattacharya, Anindya; Letavic, Michael A.
Afiliación
  • Chrovian CC; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Soyode-Johnson A; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Peterson AA; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Gelin CF; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Deng X; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Dvorak CA; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Carruthers NI; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Lord B; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Fraser I; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Aluisio L; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Coe KJ; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Scott B; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Koudriakova T; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Schoetens F; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Sepassi K; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Gallacher DJ; Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Bhattacharya A; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Letavic MA; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.
J Med Chem ; 61(1): 207-223, 2018 01 11.
Article en En | MEDLINE | ID: mdl-29211470
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridinas / Diseño de Fármacos / Receptores Purinérgicos P2X7 / Antagonistas del Receptor Purinérgico P2X Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridinas / Diseño de Fármacos / Receptores Purinérgicos P2X7 / Antagonistas del Receptor Purinérgico P2X Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article