PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by ß<sub>2</sub>-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone, Timothy B; Smith, Kaitlyn H; Koziol-White, Cynthia J; Li, Fengying; Kazarian, Austin G; Corpuz, Maia L; Shumyatcher, Maya; Ehlert, Frederick J; Himes, Blanca E; Panettieri, Reynold A; Ostrom, Rennolds S

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by ß₂-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone, Timothy B; Smith, Kaitlyn H; Koziol-White, Cynthia J; Li, Fengying; Kazarian, Austin G; Corpuz, Maia L; Shumyatcher, Maya; Ehlert, Frederick J; Himes, Blanca E; Panettieri, Reynold A; Ostrom, Rennolds S.

Afiliación

Johnstone TB; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Smith KH; 2 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Koziol-White CJ; 3 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.
Li F; 2 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Kazarian AG; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Corpuz ML; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Shumyatcher M; 4 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Ehlert FJ; 5 Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California.
Himes BE; 4 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Panettieri RA; 3 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.
Ostrom RS; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.

Am J Respir Cell Mol Biol ; 58(4): 530-541, 2018 04.

Article en En | MEDLINE | ID: mdl-29262264

Asunto(s)

3',5'-AMP Cíclico Fosfodiesterasas/metabolismo; Adenilil Ciclasas/metabolismo; Asma/enzimología; AMP Cíclico/metabolismo; Músculo Liso/enzimología; Miocitos del Músculo Liso/enzimología; Receptores Adrenérgicos beta 2/metabolismo; Sistema Respiratorio/enzimología; 3',5'-AMP Cíclico Fosfodiesterasas/genética; Adenilil Ciclasas/genética; Remodelación de las Vías Aéreas (Respiratorias); Asma/genética; Asma/patología; Asma/fisiopatología; Estudios de Casos y Controles; Proliferación Celular; Células Cultivadas; Humanos; Microdominios de Membrana/enzimología; Microdominios de Membrana/patología; Músculo Liso/patología; Músculo Liso/fisiopatología; Miocitos del Músculo Liso/patología; Receptores Adrenérgicos beta 2/genética; Sistema Respiratorio/patología; Sistema Respiratorio/fisiopatología; Sistemas de Mensajero Secundario; Factores de Tiempo

Palabras clave

PDE; adenylyl cyclase; cAMP compartmentation; lipid rafts

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sistema Respiratorio / Asma / Adenilil Ciclasas / Receptores Adrenérgicos beta 2 / AMP Cíclico / 3',5'-AMP Cíclico Fosfodiesterasas / Miocitos del Músculo Liso / Músculo Liso Tipo de estudio: Observational_studies Idioma: En Revista: Am J Respir Cell Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article

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