Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies.

Xue, Xing-He; Feng, Zhen-Hua; Li, Zhen-Xing; Pan, Xiao-Yun

Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies.

Xue, Xing-He; Feng, Zhen-Hua; Li, Zhen-Xing; Pan, Xiao-Yun.

Afiliación

Xue XH; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Feng ZH; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Li ZX; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Pan XY; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Mol Med Rep ; 17(3): 3751-3757, 2018 03.

Article en En | MEDLINE | ID: mdl-29286130

Asunto(s)

Glucósidos/farmacología; Fenoles/farmacología; Transducción de Señal/efectos de los fármacos; Animales; Apoptosis/efectos de los fármacos; Caspasa 3/metabolismo; Caspasa 9/metabolismo; Supervivencia Celular/efectos de los fármacos; Citocromos c/metabolismo; Dexametasona/toxicidad; Necrosis de la Cabeza Femoral/inducido químicamente; Necrosis de la Cabeza Femoral/patología; Necrosis de la Cabeza Femoral/veterinaria; Masculino; Ratones; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Osteoblastos/citología; Osteoblastos/efectos de los fármacos; Osteoblastos/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Ratas; Ratas Sprague-Dawley; Proteína X Asociada a bcl-2/metabolismo

Palabras clave

steroid-induced avascular necrosis of the femoral head; osteoblast; apoptosis; salidroside; phosphoinositide 3-kinase/protein kinase B signaling pathway

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenoles / Transducción de Señal / Glucósidos Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Med Rep Año: 2018 Tipo del documento: Article

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